Prefilled syringe with pegfilgrastim having optimized dose and methods related thereto

US11602598B1 · kind B1 · utility

Assignee

• Fresenius Kabi Deutschland GmbH · DE

Inventors

• Florence Roger · Santa Clara, US
• Fabien Vaudant · Grateloup, FR
• Thierry Rimlinger · L'Isle-d'Abeau, FR
• Christian Ebert · Frankfurt, DE
• Rodrigue Chatton · Echichens, CH
• Alexander Degen · Dubai, AE
• Kevin Reitz · Florstadt, DE
• Torsten Brandenburger · Reichelsheim, DE

Key dates

• Filing date: Mar 11, 2021
• Grant date: Mar 14, 2023
• Expiry date: Mar 11, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2207/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A prefilled syringe and a method of filling a syringe with a pegfilgrastim solution to provide a target extracted volume of pegfilgrastim solution from the syringe are described. A method includes selecting the target extracted volume of pegfilgrastim solution, determining an estimated drug transfer loss, determining an estimated syringe dead volume, filling the syringe with a volume of pegfilgrastim solution comprising at least the target extracted volume plus the estimated drug transfer loss plus the estimated syringe dead volume.