Antibodies binding to VISTA at acidic pH

US11603406B2 · kind B2 · utility

Assignees

• Five Prime Therapeutics, Inc. · US
• Bristol-Myers Squibb Company · US

Inventors

• Robert J. Johnston · San Mateo, US
• Arvind Rajpal · San Francisco, US
• Paul O. Sheppard · Granite Falls, US
• Luis Borges · Seattle, US
• Andrew Rankin · Redwood City, US
• Keith Sadoon Bahjat · Portland, US
• Alan J. Korman · Piedmont, US
• Andy X. Deng · Princeton, US
• Lin Hui Su · Somerville, US
• Ginger Rakestraw · Cambridge, US

Key dates

• Filing date: Mar 13, 2018
• Grant date: Mar 14, 2023
• Expiry date: Sep 5, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.