Patent · US Active

System for identification of antigens recognized by T cell receptors expressed on tumor infiltrating lymphocytes

US11603565B2 · kind B2 · utility

0Cited by

0References

15Claims

0Family size

Assignees

Roche Sequencing Solutions, Inc. · US
Ventana Medical Systems, Inc. · US

Inventors

Nelson Alexander · Marana, US
Aoune Barhoumi · Oro Valley, US
Jan Berka · New Haven, US
Rui Chen · Fremont, US
Lisa Gallegos · Tucson, US
Toumy Guettouche · Miami, US
Seoyoung Kim · Foster City, US
Maeve O'Huallachain · Pleasanton, US
Sedide Ozturk · Pleasanton, US
Jigar Patel · London, GB
Florian Rubelt · Menlo Park, US
Stacey Stanislaw · Tucson, US

Key dates

Filing date	Jun 14, 2019
Grant date	Mar 14, 2023
Priority date	—
Expiry date	Sep 10, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/56977
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.