Metal oxide nanostructured surfaces

US11608565B2 · kind B2 · utility

Assignee

• ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA · US

Inventors

• David Tyvoll · Village of La Jolla, US
• Nan Chen · Downers Grove, US
• Bharat Kumar Menon · Los Angeles, US
• Heather Michelle Grandin · San Diego, US
• Cesar Escobar Blanco · Los Angeles, US

Key dates

• Filing date: Dec 14, 2021
• Grant date: Mar 21, 2023
• Expiry date: Dec 14, 2041

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y40/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Embodiments of nanostructures comprising metal oxide and methods for forming the nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure containing both titanium oxide and nickel oxide. The nanostructure can include a lattice layer disposed on top of a nanotube layer. The distal surface of the lattice layer can have a titanium oxide to nickel oxide ratio of greater than 10:1, or about 17:1, resulting in a nanostructure that promotes human endothelial cell migration and proliferation at the interface between the lattice layer and human cells or tissue. The nanostructure may be formed on the outer surface of an implantable medical device, such a stent or an orthopedic implant (e.g. knee implant, bone screw, or bone staple).