Pharmaceutical composition and method for relieving/eliminating morphine-induced analgesic tolerance

US11612634B2 · kind B2 · utility

Assignee

• XUZHOU MEDICAL UNIVERSITY · CN

Inventors

• Qiongyao Tang · Xuzhou, CN
• Zhe Zhang · Simpsonville, US
• Chen Chen · 安丰镇, CN
• Mingxi TANG · Xuzhou, CN
• Yue TENG · Xuzhou, CN
• Nan Zhou · Eden Prairie, US
• Shaoxi Ke · Xuzhou, CN
• Ping Dong · 安丰镇, CN
• Jingjing Wang · Shanghai, CN
• Wanxin Su · Xuzhou, CN
• Xiaohui WANG · Xuzhou, CN
• Yanmei XIAO · Xuzhou, CN
• Su Liu · Xuzhou, CN
• Long Ma · Xuzhou, CN
• Jun Gan · Xuzhou, CN
• Xiaoxia Zhu · Xuzhou, CN
• Sibei Ruan · Xuzhou, CN
• Feng Ling · Nanhu, CN

Key dates

• Filing date: Dec 13, 2021
• Grant date: Mar 28, 2023
• Expiry date: Dec 13, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a pharmaceutical composition and method for relieving/eliminating morphine-induced analgesic tolerance. The pharmaceutical composition includes a therapeutically effective amount of a short peptide and morphine as active ingredients, and a pharmaceutically-acceptable carrier. The short peptide is a peptide consisting of an amino acid sequence shown in SEQ ID NO: 1 or a pharmaceutically-acceptable salt thereof. In the method, the short peptide and morphine are administered to a subject simultaneously; or the short peptide is injected to the subject followed by administration of the morphine; or a pharmaceutical composition including the short peptide and morphine is administered to the subject.