Steroid acid-based immunogen enhancers
US11612651B2 · kind B2 · utility
1Cited by
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20Claims
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Key dates
| Filing date | May 6, 2022 |
| Grant date | Mar 28, 2023 |
| Priority date | — |
| Expiry date | May 6, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6031
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunogen enhancers for admixture with an antigen of interest are described herein. The enhancers generally comprise a steroid acid and/or a steroid acid-peptide conjugate in an amount sufficient to improve or modify the adaptive immune response to antigens admixed therewith. In embodiments, the steroid acid may be a bile acid and the peptide may comprise one or more functional domains, such as a nuclear localization signal, which may facilitate antigen-presentation and/or antigen cross-presentation, thereby triggering improved cellular immunity, or improved cellular and humoral immunity, against the antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.