Proteoglycan mimetics for enhanced wound healing, angiogenesis, and vascular repair

US11612663B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• Purdue Research Foundation · US

Inventors

• Alyssa Panitch · Davis, US
• Emily Michelle Misnick · Oakland, US
• Jenny B. Lin · Oakland, US
• Kit S. Lam · Davis, US
• Ruiwu Liu · Beijing, CN
• Dake Hao · Oakland, US
• Aijun Wang · Davis, US

Key dates

• Filing date: Oct 2, 2020
• Grant date: Mar 28, 2023
• Expiry date: Oct 2, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides pro-angiogenic proteoglycan mimetics that can provide a provisional, pro-angiogenic scaffold to support tissue regeneration while limiting systemic exposure to VEGF activity. These mimetics can protect a collagen matrix from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing. For example, the provided compounds can be delivered from the end of a catheter following balloon angioplasty to coat the collagen exposed areas, prevent platelet binding and thrombosis, support capture of EPCs from blood to facilitate reendothelialization, and reduce late-lumen loss (neointimal hyperplasia).