Microencapsulation of chemicals and bioactives by in situ complex coacervation during spray drying
US11612870B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 18, 2021 |
| Grant date | Mar 28, 2023 |
| Priority date | — |
| Expiry date | Jun 20, 2041 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J13/043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. The one-step spray drying process utilizes formulations of a first ionic polymer, a second ionic polymer with an isoelectric point (pI2) or acid dissociation constant (pKa2) that is greater than the isoelectric point (pI1) or acid dissociation constant (pKa1) of the first ionic polymer and a volatile base or volatile acid. Volatilization of the volatile base or acid of the spray formulation changes the pH of the solution and changes the charge of the second ionic polymer initiating electrostatic interactions with the first ionic polymer through complex coacervation. Microcapsules formed by the complex coacervation process can stabilize bioactive components as well as control the release of the bioactive components for a variety of applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.