Identifying human B cells expressing anti-allergen antibodies

US11613569B2 · kind B2 · utility

Assignees

• CZ Biohub SF, LLC · US
• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Derek Croote · Stanford, US
• Stephen R. Quake · Pasadena, US
• Kari C. Nadeau · Los Altos Hills, US
• Spyros Darmanis · San Francisco, US
• David N. Cornfield · Stanford, US

Key dates

• Filing date: Jun 17, 2021
• Grant date: Mar 28, 2023
• Expiry date: Jun 17, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.