Chimeric antibody/T-cell receptor constructs and uses thereof

US11613573B2 · kind B2 · utility

Assignee

• Eureka Therapeutics, Inc. · US

Inventors

• Lucas HORAN · Emeryville, US
• Yiyang Xu · Pleasanton, US
• Zhiyuan Yang · Albany, US
• Hong Liu · Seattle, US
• Javier Morales · Emeryville, US
• Lianxing Liu · San Francisco, US

Key dates

• Filing date: Apr 24, 2018
• Grant date: Mar 28, 2023
• Expiry date: Jul 12, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/43
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule. Also provided are methods of making and using these constructs.