Methods and compositions relating to ex vivo culture and modulation of T cells
US11613574B2 · kind B2 · utility
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17Claims
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Assignee
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Key dates
| Filing date | Jan 10, 2018 |
| Grant date | Mar 28, 2023 |
| Priority date | — |
| Expiry date | Jul 8, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are methods for producing and utilizing an artificial antigen presenting cell (aAPC). An aAPC is engineered to express a first and second chimeric stimulatory receptor that specifically bind antigen presenting on a T cell of interest. The aAPC as described herein is designed for use in activating and/or expanding a T cell or chimeric antigen receptor (CAR) T cell. Further, this invention relates to methods of treating cancer by administering to a subject in need thereof an aAPC-activated CART cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.