Toxic RNAi active seed sequences for killing cancer cells
US11613754B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Feb 20, 2018 |
| Grant date | Mar 28, 2023 |
| Priority date | — |
| Expiry date | Apr 26, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be utilized for treating diseases and disorders through RNAi. Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.”
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.