High intensity labeled reactant compositions and methods for sequencing
US11613772B2 · kind B2 · utility
1Cited by
74References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 23, 2020 |
| Grant date | Mar 28, 2023 |
| Priority date | — |
| Expiry date | Jan 23, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2458/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.