Method for preparing 3-chloro-4-oxopentyl acetate using fully continuous-flow micro-reaction system

US11618727B2 · kind B2 · utility

Assignee

• FUDAN UNIVERSITY · CN

Inventors

• Fener CHEN · Shanghai, CN
• Meifen JIANG · Shanghai, CN
• Minjie LIU · Shanghai, CN
• Dang CHENG · Shanghai, CN
• Chao YU · Shanghai, CN
• Huashan HUANG · Shanghai, CN

Key dates

• Filing date: Jul 24, 2021
• Grant date: Apr 4, 2023
• Expiry date: Jul 26, 2041

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2219/00894
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This disclosure relates to organic synthesis, and more particularly to a method for preparing 3-chloro-4-oxopentyl acetate using a fully continuous-flow micro-reaction system. In this method, chlorine and an acetylbutyrolactone-containing liquid are simultaneously transported to a first micro-channel reactor for continuous chlorination to obtain α-acetyl-α-chloro-γ-butyrolactone. The reaction mixture is simultaneously transported to a micro-mixer and a second micro-channel reactor together with a mixed solution of glacial acetic acid, hydrochloric acid and water, and the continuous acylation is carried out to obtain 3-chloro-4-oxopentyl acetate. After quenched with a quenching agent, the reaction mixture was subjected to extraction and separation to obtain the 3-chloro-4-oxopentyl acetate.