Process for the synthesis of n-substituted lactams and amides

US11618732B2 · kind B2 · utility

Assignee

• ADVANSIX RESINS & CHEMICALS LLC · US

Inventors

• Xiawei Zhang · West Chester, US
• Robert Schutter, Jr. · Sewell, US
• Lihao Tang · Bound Brook, US
• Scott R. Keenan · Marlton, US
• Xin Li · Shanghai, CN

Key dates

• Filing date: Dec 8, 2020
• Grant date: Apr 4, 2023
• Expiry date: Jul 9, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D223/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.