LXR modulators with bicyclic core moiety

US11618747B2 · kind B2 · utility

Assignee

• OrsoBio, Inc. · US

Inventors

• Christian Gege · Ehingen (Donau), DE
• Olaf Kinzel · Heidelberg, DE
• Eva Hambruch · Mannheim, DE
• Manfred Birkel · Seeheim-Jugenheim, DE
• Claus Kremoser · Heidelberg, DE
• Ulrich Deuschle · Bammental, DE

Key dates

• Filing date: Jun 28, 2019
• Grant date: Apr 4, 2023
• Expiry date: Jun 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to bicyclic compounds (e.g. indoles) containing a sulfonyl moiety, which bind to the liver X receptor (LXRα and/or LXKβ) and act preferably as inverse agonists of LXR.