Compounds and compositions for treating conditions associated with STING activity

US11618749B2 · kind B2 · utility

Assignee

• IFM Due, Inc. · US

Inventors

• William R. Roush · West Jupiter, US
• Shankar Venkatraman · Lansdale, US
• Gary D. Glick · Ann Arbor, US
• Hans Martin Seidel · Concord, US

Key dates

• Filing date: Jul 2, 2019
• Grant date: Apr 4, 2023
• Expiry date: Jul 2, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This disclosure features chemical entities of formula I (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.