Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells
US11618885B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Oct 31, 2016 |
| Grant date | Apr 4, 2023 |
| Priority date | — |
| Expiry date | Dec 24, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/2315
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to the expansion of non-haematopoietic tissue-resident γδ T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident γδ T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident γδ T cells and uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.