Probe for measuring activity of Caspase-1 and composition for diagnosis of inflammatory diseases containing same
US11618916B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 12, 2019 |
| Grant date | Apr 4, 2023 |
| Priority date | — |
| Expiry date | Jul 13, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96466
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A probe for measuring the activity of caspase-1 according to the present disclosure can specifically image cells or tissues where inflammatory response is induced because it is cleaved by reacting specifically with the active caspase-1 enzyme in vivo and in vitro and re-emits fluorescence. The probe for measuring the activity of caspase-1 can be used for various purposes, such as for imaging of cells or tissues where inflammatory response is induced, as a drug carrier, for screening of a drug inhibiting inflammatory response, etc.The probe for measuring the activity of caspase-1 is applicable both in vivo and in vitro, and can be used for various applications such as high-throughput screening for new drug development, early diagnosis of diseases, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.