Ultra-sensitive detection of molecules or particles using beads or other capture objects
US11619631B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 11, 2019 |
| Grant date | Apr 4, 2023 |
| Priority date | — |
| Expiry date | Feb 15, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54313
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.