Method for destroying cellular mechanical homeostasis and promoting regeneration and repair of tissues and organs, and use thereof
US11622964B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 2019 |
| Grant date | Apr 11, 2023 |
| Priority date | — |
| Expiry date | Feb 15, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P17/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a method for destroying cellular mechanical homeostasis and the use thereof, especially disclosed is a method for destroying cellular mechanical homeostasis by using a Myosin inhibitor thereby leading to cell softening and reduction of fibrosis in tissues and organs. Also disclosed are a method for promoting regeneration and repair of tissues and organs and the use thereof. The Myosin inhibitor can destroy the homeostasis of the cellular mechanical stress system, reduce the rigidity of tissues and organs in a pathological state, and stimulate stress and regeneration reactions similar to those in the regeneration processes in lower organisms; and can use the characteristics to greatly inhibit fibrosis during the organ damage and to promote the regeneration and repair of tissues and organs, and meanwhile can use stress response to greatly improve the ability of cellular genetic repair. The Myosin inhibitor is preferably (−)-Blebbistatin, or a derivative thereof (−)-Blebbistatin O-Benzoate. The method requires only a single small molecule or single factor treatment, and is simple in operation and good in repeatability, and can be used as a new method to stimulate stress …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.