Compositions and methods for viral cancer neoepitopes
US11623001B2 · kind B2 · utility
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Key dates
| Filing date | Oct 12, 2016 |
| Grant date | Apr 11, 2023 |
| Priority date | — |
| Expiry date | Oct 12, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for preparation and use of recombinant viruses or other recombinant expression systems are presented in which neoepitopes are first identified in a patient- and cancer-specific manner and then further filtered by HLA-match to the patient. Selected neoepitopes are then expression using sequence elements that direct the expressed neoepitope to the HLA-type (MHC-I and/or MHC-II subtype) that has desirable affinity to the filtered neoepitope.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.