Prodruggable antibodies, prodrugs thereof, and methods of use and making

US11623965B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Stanley Krystek · Ringoes, US
• Yong Zhang · Plainsboro, US
• Gregory D. Vite · Titusville, US
• Arvind Rajpal · San Francisco, US
• Chetana Rao-Naik · Walnut Creek, US
• Paul E. Morin · Pennington, US
• Mohan Srinivasan · Cupertino, US
• Zheng Lin · North Wales, US
• Virginie Lafont · Lawrence, US
• Alla Pritsker · Cambridge, US

Key dates

• Filing date: Aug 14, 2018
• Grant date: Apr 11, 2023
• Expiry date: May 17, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y304/21109
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.