Methods and systems for performing single cell analysis of molecules and molecular complexes

US11624062B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• Rustem F. Ismagilov · Altadena, US
• Matthew S. Curtis · Pasadena, US
• Mary ARRASTIA · Pasadena, US
• David A. Selck · Sterling, US
• Mitchell Guttman · Cambridge, US

Key dates

• Filing date: Sep 25, 2018
• Grant date: Apr 11, 2023
• Expiry date: Sep 25, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B70/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods, systems and related compositions are provided to perform single-cell marking of a nucleic acid and/or protein in a sample based on in-cell or in-organelle barcoding of nucleic acid and/or protein complexes of the cell or organelle; the methods and systems herein described are configured to provide in-cell or in-organelle single-cell marked nucleic acid and/or protein complexes comprising a single-cell, cell-specific, or a single-cell organelle-specific marker.