99mTc-labeled isonitrile-containing glucose derivative and preparation method and use thereof

US11628228B2 · kind B2 · utility

Assignee

• Beijing Shihong Pharmaceutical Research Center · CN

Inventors

• Junbo Zhang · Beijing, CN
• Xuran Zhang · Beijing, CN
• Qianqian Gan · Beijing, CN
• Xin Shao · Beijing, CN
• Xuebin Wang · Beijing, CN
• Zhigang Tang · Beijing, CN
• Jie Lu · Beijing, CN
• Zhanbin Zhang · Beijing, CN

Key dates

• Filing date: Jan 24, 2018
• Grant date: Apr 18, 2023
• Expiry date: Oct 2, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A 99mTc-labeled isonitrile-containing glucose derivative having the general formula [99mTc-(CNDG)6]+, preparation method and use thereof is disclosed herein. The derivative is centered on 99mTc+, and the carbon atom of the isonitrile in CNDG coordinates with 99mTc(I) to form a hexacoordinated complex [99mTc-(CNDG)6]+. The [99mTc-(CNDG)6]+ derivative was obtained by the synthesis of the ligand CNDG and the preparation of the lyophilized CNDG kit. The derivative of this disclosure has good stability, simple preparation, high uptake and good retention at a tumor site, and high tumor/non-target ratio, and it is a novel 99mTc-labeled isonitrile-containing glucose derivative with excellent performance for tumor imaging. The derivative of this disclosure is advantageous for popularization and application.