Microfluidic system for evaluation of chemotherapeutic and immunotherapeutic drugs

US11628437B2 · kind B2 · utility

Assignee

• The Charles Stark Draper Laboratory, Inc. · US

Inventors

• Jeffrey T. Borenstein · Holliston, US
• Alla A. Gimbel · Tampa, US
• Jose A. Santos · Westwood, US
• Daniel Doty · Arlington, US
• Nathan Moore · Canton, US
• Louis Kratchman · Quincy, US
• James Gillett Truslow · Boston, US

Key dates

• Filing date: Mar 30, 2018
• Grant date: Apr 18, 2023
• Expiry date: Jun 17, 2041

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/086
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Systems and methods for conducting assays on tissue fragment samples including providing a suspension maintaining pump, and a plurality of fluid reservoirs, wherein the fluid reservoirs are configured to hold a volume of fluid. The fluid reservoirs are fluidically coupled to a microfluidic assay chip, wherein the microfluidic assay chip includes a plurality of parallel assay channels, a first inlet port for introduction of a tissue fragment sample into the microfluidic assay ship, and a second inlet port coupled to the fluid reservoir. Each channel of the microfluidic assay chip also includes a retention barrier configured to trap the tissue fragment sample such that the fluid perfuses through the tissue sample, as well as an outlet port fluidically coupled to a waste receptacle.