Patent · US Active

IRE1 small molecule inhibitors

US11634403B2 · kind B2 · utility

1Cited by

2References

22Claims

0Family size

Assignee

Cornell University · IT

Inventors

Joseph P. Vacca · Telford, US
Dansu Li · New York, US
Sarah Elizabeth Bettigole · New York, US

Key dates

Filing date	Feb 15, 2021
Grant date	Apr 25, 2023
Priority date	—
Expiry date	Jun 5, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.