B-cell epitope of Trichinella spiralis cysteine protease inhibitor, hybridoma cell line, monoclonal antibody and uses thereof
US11634481B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2020 |
| Grant date | Apr 25, 2023 |
| Priority date | — |
| Expiry date | Jul 15, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/8139
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure relates to the field of immunology, in particular to a B-cell epitope of Trichinella spiralis cysteine protease inhibitor, a hybridoma cell line, a monoclonal antibody and uses thereof. The present disclosure provides a hybridoma cell line that can generate anti-WN10 antibody, and identifies the specific B-cell epitope of WN10 protein recognized by the monoclonal antibody. These are of great significance for the diagnosis of trichinellosis, for the establishment of competitive ELISA for detecting antibodies and sandwich ELSIA for detecting circulating antigens, for the detection of Trichinella spiralis in different hosts and for the development of subunit vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.