Methods and compositions for inducing hematopoietic cell differentiation
US11634688B2 · kind B2 · utility
2Cited by
41References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2020 |
| Grant date | Apr 25, 2023 |
| Priority date | — |
| Expiry date | Jan 25, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/90
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides culture platforms, cell media, and methods of differentiating pluriptent cells into hematopoietic cells. The invention further provides pluripotent stem cell-derived hematopoietic cells generated using the culture platforms and methods disclosed herein, which enable feed-free, monolayer culturing and in the absence of EB formation. Specifically, pluripotent stem cell-derived hematopoietic cell of this invention include, and not limited to, iHSC, definitive hemogenic endothelium, hematopoietic multipotent progenitors, T cell progenitors, NK cell progenitors, T cells, and NK cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.