Oligonucleotide compositions and methods thereof

US11634710B2 · kind B2 · utility

Assignee

• WAVE LIFE SCIENCES LTD. · SG

Inventors

• Maria Frank-Kamenetsky · Brookline, US
• Hailin Yang · Riverdale, US
• Aaron Morris · Watertown, US
• Chandra Vargeese · Schwenksville, US
• Christopher J. Francis · Arlington, US

Key dates

• Filing date: Feb 4, 2020
• Grant date: Apr 25, 2023
• Expiry date: Aug 25, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/346
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.