Methods and devices for integrating analyte extraction, concentration and detection

US11635432B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Daniel Takashi Kamei · Monterey Park, US
• Yin To Chiu · Irvine, US
• Benjamin M. Wu · San Marino, US
• Garrett L. Mosley · Anaheim, US

Key dates

• Filing date: Jan 23, 2020
• Grant date: Apr 25, 2023
• Expiry date: Mar 14, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/54366
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.