Double-labeled probe for molecular imaging and use thereof

US11638765B2 · kind B2 · utility

Assignees

• Deutsches Krebsforschungszentrum · DE
• RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

• Matthias Eder · Freiburg (Elbe), DE
• Klaus Kopka · Dossenheim, DE
• Martin Schaefer · Penzberg, DE
• Ulrike Bauder-Wuest · Schriesheim, DE
• Uwe Haberkorn · Schwetzingen, DE
• Ann-Christin EDER · Simonswald, DE
• Jens Cardinale · Wien, AT
• Martina Benesova · Neckarsteinach, DE

Key dates

• Filing date: Nov 20, 2018
• Grant date: May 2, 2023
• Expiry date: May 31, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.