Hematopoietic stem cell engraftment

US11642379B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• The Regents of the University of California · US

Inventors

• Rajni Agarwal · Redwood City, US
• Janel Long Boyle · Redwood City, US
• Morton J. Cowan · Kentfield, US
• Christopher Dvorak · Redwood City, US
• Hye-Sook Kwon · San Mateo, US
• Anne Le · Baltimore, US
• Aaron Logan · Redwood City, US
• Wendy Pang · Redwood City, US
• Robertson Parkman · Redwood City, US
• Maria Grazia Roncarolo · Milano, IT
• Kenneth Weinberg · Stanford, US
• Judith A. Shizuru · Palo Alto, US
• Susan Sweeney Prohaska · Mountain View, US
• Agnieszka Czechowicz · Boston, US
• Irving L. Weissman · Palo Alto, US

Key dates

• Filing date: Dec 7, 2018
• Grant date: May 9, 2023
• Expiry date: May 3, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2999/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides clinical evidence for a method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring myeloablative conditioning.