Compositions containing a pharmacophore with selectivity to diseased tissue and methods of making same
US11642391B2 · kind B2 · utility
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Key dates
| Filing date | Aug 4, 2015 |
| Grant date | May 9, 2023 |
| Priority date | — |
| Expiry date | Mar 20, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16C20/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.