Compositions and methods for treating cardiovascular related disorders

US11642419B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Anna A. Schwendeman · Ann Arbor, US
• Yuqing E. Chen · Ann Arbor, US
• Yanhong Guo · Ann Arbor, US
• Jifeng Zhang · Newbury Park, US
• Wenmin Yuan · Ann Arbor, US
• Emily Morin · Ann Arbor, US

Key dates

• Filing date: Mar 25, 2016
• Grant date: May 9, 2023
• Expiry date: Dec 14, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to nanoparticles complexed with therapeutic agents configured for treating cardiovascular related disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising synthetic HDL (sHDL) nanoparticles carrying therapeutic agents configured for treating cardiovascular related disorders, methods for synthesizing such sHDL nanoparticles, as well as systems and methods utilizing such sHDL nanoparticles (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutic agents, imaging agents, and/or targeting agents (e.g., in cardiovascular disease diagnosis and/or therapy, etc.))).