Metal organic frameworks for removal of elemental impurities in pharmaceutical products
US11642650B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 2021 |
| Grant date | May 9, 2023 |
| Priority date | — |
| Expiry date | May 13, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F15/02
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
This invention relates to a method of using MOF adsorbents to remove elemental impurities from feed streams comprising active pharmaceutical ingredients (API). The process involves contacting the feed stream comprising API and elemental impurities with the MOF at purification conditions to obtain a purified stream with provides an API which has a concentration of the elemental impurity below its permitted daily exposure. The process can be carried in a batch mode where the MOF and feed stream are admixed in a vessel for a given amount of time or continuously by flowing the feed stream through a column or adsorbent bed containing the MOF adsorbent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.