Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof

US11643380B2 · kind B2 · utility

Assignee

• Canopy Growth Corporation · CA

Inventors

• Daniel BRUMAR · Smiths Falls, CA
• Mahmood Azizpour FARD · Smiths Falls, CA
• Ben GEILING · Smiths Falls, CA
• Mohammadmehdi HAGHDOOST MANJILI · Smiths Falls, CA

Key dates

• Filing date: Mar 21, 2022
• Grant date: May 9, 2023
• Expiry date: Mar 21, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/343
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof.