Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease

US11643394B2 · kind B2 · utility

Assignees

• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US
• United States Government as represented by the Department of Veterans Affairs · US
• The Research Foundation for The State University of New York · US

Inventors

• Sandeep Mallipattu · Saint James, US
• Bhaskar C. Das · West Nyack, US

Key dates

• Filing date: Apr 29, 2021
• Grant date: May 9, 2023
• Expiry date: Apr 29, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is concerned with small molecule modulators of KLF15 signaling useful for treating various disorders such as, for example, kidney disease (e.g., chronic kidney disease), heart disease, obesity, or a neurodegenerative disorder (e.g., amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, traumatic brain injury, vascular dementia, Huntington's disease, mental retardation, and attention deficit and hyperactivity disorder (ADHD)). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.