Multi-target compound with anticoagulation and antiplatelet activity, preparation method therefor, and use thereof
US11643439B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 2015 |
| Grant date | May 9, 2023 |
| Priority date | — |
| Expiry date | Oct 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K9/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a multi-target compound with anticoagulation and platelet GPIIb/IIIa receptor antagonism. The formula of the multi-target compound is as follows: A-L-B-L′-C. A and B are binding sites with a thrombin, C is a binding site with a platelet GPIIb/IIIa receptor, L is a first linking group, and L′ is a second linking group. Also provided are a preparation method for the compound and use of the compound. The compound has the effects on inhibiting human thrombin activity and a platelet GPIIb/IIIa receptor in vitro, and has the effects on antiplatelet aggregation in vitro/in vivo, and anticoagulation and antithrombosis in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.