T cell receptor
US11643451B2 · kind B2 · utility
1Cited by
0References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2017 |
| Grant date | May 9, 2023 |
| Priority date | — |
| Expiry date | May 19, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
TCR The present invention relates to an engineered T cell receptor (TCR). In particular, the present invention relates to methods for expression of a TCR when expressed as an exogenous TCR, to methods for selecting a TCR with high cell surface expression when expressed as an exogenous TCR and to methods for identifying residues which contribute to the cell surface expression level of a TCR. The present invention also relates to an engineered TCR which has a high level of cell surface expression when expressed as an exogenous TCR compared to the corresponding germline TCR sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.