T cell-antigen coupler with Y182T mutation and methods and uses thereof
US11643472B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Oct 12, 2018 |
| Grant date | May 9, 2023 |
| Priority date | — |
| Expiry date | Dec 14, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.