Methods for intracellular delivery and enhanced gene targeting
US11643655B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Nov 15, 2017 |
| Grant date | May 9, 2023 |
| Priority date | — |
| Expiry date | Nov 15, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are methods and compositions for enhancing gene targeting. The method entails co-administrating to a cell a targeting molecule and a means of enhancing the function of the targeting molecule upon delivery to the cell. The means of enhancing the function of the targeting molecule including one or more of a stressor that induces cellular stress, a proton sponge molecule, and an endosome or lysosome inhibitor. Compositions disclosed include a targeting molecule and one or more of a stressor that induces cellular stress, a proton sponge molecule, and an endosome or lysosome inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.