Artificial tympanic membrane devices and uses

US11648106B2 · kind B2 · utility

Assignees

• Massachusetts Eye and Ear Infirmary · US
• President and Fellows of Harvard College · US

Inventors

• Aaron K. Remenschneider · Boston, US
• Elliott Kozin · Boston, US
• Nicole Black · Shelby Charter Township, US
• Michael McKenna · Boston, US
• Daniel J. Lee · Brookline, US
• Jennifer A. Lewis · Cambridge, US
• John Rosowski · Arlington, US
• David B. Kolesky · Cambridge, US
• Mark A. Skylar-Scott · Brookline, US
• Alexander D. Valentine · Windham, US

Key dates

• Filing date: Sep 22, 2020
• Grant date: May 16, 2023
• Expiry date: Jun 23, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/14
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a “lock and key” manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.