Extended release pharmaceutical composition of Clozapine
US11648207B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 8, 2022 |
| Grant date | May 16, 2023 |
| Priority date | — |
| Expiry date | Apr 8, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0053
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is an extended release pharmaceutical composition of Clozapine, which can be provided as a reservoir type dosage form, and when dosed to a patient once daily achieves at steady state, AUC0-24h, Cmax and Cmin in patient plasma that are within 80 to 125% bioequivalence criteria compared to immediate release Clozapine dosed at the same total daily dose divided twice per day. Further, the pharmaceutical composition of Clozapine can provide once daily dosing regimen in order to improve patient compliance and reduces side effects in patients in need thereof. The pharmaceutical composition further lacks any significant food effect on oral administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.