Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids
US11649446B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 2019 |
| Grant date | May 16, 2023 |
| Priority date | — |
| Expiry date | Aug 9, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y601/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.