Evolution of bioactive sequence-defined synthetic polymers using DNA-templated polymerization
US11649451B2 · kind B2 · utility
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Key dates
| Filing date | Jul 6, 2018 |
| Grant date | May 16, 2023 |
| Priority date | — |
| Expiry date | Sep 11, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for performing ordered multi-step syntheses involving modified nucleic acids by nucleic acid-mediated chemistry. This approach is useful for generating sequence-defined highly functionalized nucleic acid polymers. The invention also provides modified nucleic acid polymers that bind to proteins of interest (e.g., PCSK9 and IL-6), which are implicated in human disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.