Micro RNA expression constructs and uses thereof

US11649455B2 · kind B2 · utility

Assignees

• UNIVERSITY OF GENEVA · CH
• LES HÔPITAUX UNIVERSITAIRES DE GENÈVE · CH
• Universitat Zurich · CH

Inventors

• Karl-Heinz Krause · Neuenrade, DE
• Francis Rousset · Geneva, CH
• Patrick Salmon · Arenthon, FR
• Marco Alessandrini · Geneva, CH
• Roberto Speck · Zürich, CH
• Simon Bredl · Zürich, CH
• Tafadzwa Mlambo · Zürich, CH
• Renier Myburgh · Zürich, CH

Key dates

• Filing date: Apr 1, 2019
• Grant date: May 16, 2023
• Expiry date: Apr 1, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.