Patent · US Active

Assays and reagents for antimicrobial susceptibility testing

US11649477B2 · kind B2 · utility

0Cited by
3References
22Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 9, 2019
Grant dateMay 16, 2023
Priority date—
Expiry dateJul 15, 2041

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2201/0446
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Systems and methods for antimicrobial susceptibility testing (AST) are provided in which variances in anionic charge of microbes are taken into account. Cationic surfactants may be used to sensitize otherwise resistant microorganisms to polycationic antibiotics, such as polymyxins. Since microorganisms gain polycationic antibiotic resistance through mutations that decrease surface anionic charge, the susceptibility of a microorganism to a polycationic antibiotic may be indicative of its surface charge. In order to enable electrostatic interactions with the microorganism surface, a cationic surfactant may be applied to increase the anionic charge of the microorganism.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.