TTField treatment with optimization of electrode positions based on low frequency (<1MHZ) AC conductivity estimates derived from two MRI images having different repetition times
US11650277B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 9, 2019 |
| Grant date | May 16, 2023 |
| Priority date | — |
| Expiry date | Dec 5, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/58
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A 3D model of AC electrical conductivity (at a given frequency) of an anatomic volume can be created by obtaining two MRI images of the anatomic volume, where the two images have different repetition times. Then, for each voxel in the anatomic volume, a ratio IR of the intensity of the corresponding voxels in the two MRI images is calculated. This calculated IR is then mapped into a corresponding voxel of a 3D model of AC electrical conductivity at the given frequency. The given frequency is below 1 MHz (e.g., 200 kHz). In some embodiments, the 3D model of AC electrical conductivity at the given frequency is used to determine the positions for the electrodes in TTFields (Tumor Treating Fields) treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.