Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives

US11654124B2 · kind B2 · utility

Assignee

• AMNEAL PHARMACEUTICALS LLC · US

Inventors

• David Penake · San Francisco, US
• Sharon Hamm · Land O' Lakes, US
• Leonard O'Mahony · Mullingar, IE
• John Devane · Dublin, IE
• Wolfgang Mohr · Freiburg (Elbe), DE
• Manuel Weinheimer · Neustadt an der Weinstraße, DE

Key dates

• Filing date: May 28, 2020
• Grant date: May 23, 2023
• Expiry date: May 28, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P21/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions including an active ingredient and a stabilizer, as well as methods of manufacture of the compositions, and methods of their use. The composition may include the active ingredient dispersed throughout a matrix of the stabilizer. In some embodiments, the active ingredient and the stabilizer are intimately mixed in a matrix formulation. In some embodiments, the active ingredient is selected from 4 amino-3-(4-chlorophenyl)butanoic acid) (“baclofen”) and its pharmaceutically acceptable salts.